Lingappa - ER/Golgi

Matlack et al.

Mellman et al.

Lencer et al.

Schmitz et al.

Vembar et al.

Charpian et al.

Jani et al.

Lingappa Techniques

Thielen Techniques

Marsh et al.

Marsh et al. 2

Welsch et al.

Beckham et al.

Mir et al.

Papers

Student assignments

Galloway - Cell division

Wang et al.

Schnapp - ECM

Paper Notes

Jiang et al.

O'Neill et al.

Sherman - Bacterial Secretion

Natale et al.

Champion et al.

Fink et al.

Kroemer et al.

Presentation Papers

Student assignments

Lingappa - Signaling

Pawson et al.

Primary papers:

O'Sullivan et al.

Brennan et al.

Gale - Innate immunity

Kato et al.

Saito et al.

Primary Papers:

Hornung et al.

Kato et al. 2

Myong et al.

Thielen - Intrinsic Immunity

Textbook pp 316-326 (mobile genetic elements)

Bieniasz (required intrinsic immunity review)

Wolf & Goff (recommended intrinsic immunity review)

Exam and Proposal Handout

Primary paper:

Soroceanu et al.

Primary Paper:

Neil et al.

Goettlinger commentary

Presentation Papers

Presentation Paper Assignments

Klein - cytoskeleton

Chapter 16 in Alberts

Gougin et al.

Domann et al.

Primary papers:

Brieher et al.

Lingappa - cross-presentation

Required textbook chapter: Janeway (Immunobiology), Ch. 5, p. 169-191; Ch. 8, p. 319-335.

Required literature review: Lin et al.

Primary paper: Delamarre et al.

E.  Learning Objectives:
1.  Learn types of dendritic cells and their functions.
2.  How are responses to dendritic cells modulated?
3.  What cell biologic events occur during dendritic cell maturation?
4.  How do pathogens interfere with antigen presentation?

Duffy - cellular immunology: parasites

Required reading: Abbas Chapter 15:  Immunity to Microbes

Recommended Reviews:

1.   Stevenson MM, Riley EM.Innate immunity to malaria.  Nat Rev Immunol. 2004 Mar;4(3):169-80. Review.

2.  Greenwood BM, Fidock DA, Kyle DE, Kappe SH, Alonso PL, Collins FH, Duffy PE. 2008. Malaria: progress, perils, and prospects for eradication. J Clin Invest. 118(4):1266-76. Review

Primary papers:

1.    Ocana-Morgner, C. et al. Malaria blood stage suppression of liver stage immunity by dendritic cells.  J Exp Med;197(2):143 (2003).

2.   Muehlenbachs A, Mutabingwa TK, Edmonds S, Fried M, Duffy PE. 2006. Hypertension and maternal-fetal conflict during placental malaria. PLoS Med. 3(11):e446.

Presentation Session 4 Papers

Presentation Assignments

Sodora - cellular immunology: viruses

Required textbook chapters: Flint SJ et al. Principles of Virology: Chapters 14 (review), 15

Recommended literature review: Silvestri G, Paiardini M, Pandrea I, Lederman MM, Sodora DL.  Understanding the benign nature of SIV infection in natural hosts. J Clin Invest  2007; 117(11):3148-54.

LINK: Click to go to article

Primary papers:

Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host. Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL. J Immunol  2007; 179(5):3047-56.

LINK: Click to go to article